As we approach the pinnacle of the alcohol poisoning holiday season, this op-ed seems appropriate and may give us pause:

NYT - The Hangover That Lasts

The binges activate an inflammatory response in rat brains rather than a pure regrowth of normal neuronal cells. Even after longstanding sobriety this inflammatory response translates into a tendency to stay the course, a diminished capacity for relearning and maladaptive decision-making.

(emphasis mine)

I can't help thinking that stay the course is a jab at the infamous drug and alcohol abusing history and resulting policies of the decider-in-chief.